Klaus-Peter Knobeloch Selected Research

Infections

2/2024	ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
10/2021	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.
11/2020	Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
1/2020	IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell-Dependent Route.
11/2019	The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.
1/2018	Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α+ Dendritic Cells at the Site of Infection.
1/2018	The probacterial effect of type I interferon signaling requires its own negative regulator USP18.
3/2016	NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.
8/2015	ISG15 counteracts Listeria monocytogenes infection.
10/2014	Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.

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Klaus-Peter Knobeloch Research Topics

Disease

11	Infections 02/2024 - 01/2010
5	Virus Diseases (Viral Diseases) 12/2023 - 01/2007
3	Inflammation (Inflammations) 01/2020 - 12/2011
3	Hypersensitivity (Allergy) 02/2015 - 08/2005
2	Gliosis 10/2023 - 01/2021
2	Carcinogenesis 01/2020 - 01/2020
2	Neoplasms (Cancer) 01/2020 - 01/2020
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017 - 05/2008
2	Neuroinflammatory Diseases 01/2017 - 11/2016
2	Vesicular Stomatitis 01/2007 - 08/2005
1	Atrophy 02/2024
1	Epilepsy (Aura) 10/2023
1	Temporal Lobe Epilepsy 10/2023
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 10/2021
1	Moyamoya Disease (Moya-Moya Disease) 10/2021
1	COVID-19 11/2020
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2020
1	Chromosome Breakage 01/2020
1	Pituitary Neoplasms (Pituitary Adenoma) 12/2019
1	Pituitary ACTH Hypersecretion 12/2019
1	Bacterial Infections (Bacterial Infection) 01/2018
1	Cerebral Malaria 01/2017
1	Adams Oliver syndrome 10/2016
1	Mycoses (Diseases, Fungus) 03/2016
1	Opportunistic Infections (Opportunistic Infection) 03/2016
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016
1	Bites and Stings (Sting) 08/2015
1	Myocarditis (Carditis) 10/2014
1	Heart Failure 10/2014
1	Cardiomyopathies (Cardiomyopathy) 10/2014
1	Relapsing-Remitting Multiple Sclerosis 01/2012
1	Multiple Sclerosis 12/2011
1	Encephalitis (Encephalitis, Rasmussen) 12/2011
1	Demyelinating Diseases (Demyelinating Disease) 04/2011
1	Central Nervous System Diseases (CNS Diseases) 04/2011
1	Human Influenza (Influenza) 01/2007
1	Dwarfism 08/2005
1	Achondroplasia 08/2005
1	Brain Injuries (Brain Injury) 08/2005
1	Obesity 01/2005
1	Body Weight (Weight, Body) 01/2005
1	Hyperplasia 12/2002
1	Myeloid Leukemia (Leukemia, Myelocytic) 05/2002
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 02/2002

Drug/Important Bio-Agent (IBA)

11	Interferon Type IIBA 02/2024 - 01/2007
9	Proteins (Proteins, Gene)FDA Link 02/2024 - 08/2005
9	InterferonsIBA 12/2023 - 08/2005
5	EnzymesIBA 02/2024 - 08/2005
5	UbiquitinsIBA 10/2021 - 08/2005
5	Antiviral Agents (Antivirals)IBA 11/2020 - 08/2005
4	UbiquitinIBA 12/2023 - 01/2007
3	Transcription Factors (Transcription Factor)IBA 03/2016 - 02/2002
3	Peptide Hydrolases (Proteases)FDA Link 02/2015 - 08/2012
2	Glucose (Dextrose)FDA LinkGeneric 02/2024 - 01/2005
2	CytokinesIBA 01/2018 - 08/2015
2	RNA (Ribonucleic Acid)IBA 01/2017 - 12/2011
2	Interferon-betaIBA 01/2012 - 05/2008
2	interferon regulatory factor-8 (interferon consensus sequence binding protein)IBA 05/2002 - 02/2002
1	HexokinaseIBA 02/2024
1	PhosphofructokinasesIBA 02/2024
1	Adenosine Triphosphate (ATP)IBA 02/2024
1	Viral ProteinsIBA 12/2023
1	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2023
1	Antigen-Antibody Complex (Immune Complex)IBA 10/2023
1	Ubiquitin-Specific ProteasesIBA 10/2023
1	Kainic Acid (Kainate)IBA 10/2023
1	Viral AntigensIBA 01/2021
1	AlarminsIBA 01/2020
1	Adrenocorticotropic Hormone (ACTH)FDA Link 12/2019
1	Cysteine (L-Cysteine)FDA Link 01/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2017
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 10/2016
1	CalcineurinIBA 03/2016
1	Actin Depolymerizing Factors (Cofilins)IBA 03/2016
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2016
1	Protein Isoforms (Isoforms)IBA 03/2016
1	ChemokinesIBA 03/2016
1	Tacrolimus (Prograf)FDA LinkGeneric 03/2016
1	exodeoxyribonuclease IIBA 01/2016
1	Bacterial DNAIBA 08/2015
1	Peptide Initiation Factors (Initiation Factor)IBA 10/2014
1	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA 10/2014
1	CollagenIBA 10/2014
1	OligonucleotidesIBA 12/2011
1	LigandsIBA 12/2011
1	Phosphotransferases (Kinase)IBA 04/2011
1	NF-kappa B (NF-kB)IBA 04/2011
1	2-5A-dependent ribonuclease (RNase L)IBA 01/2007
1	Poly IIBA 12/2005
1	Mitogen-Activated Protein KinasesIBA 08/2005
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 08/2005
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2005
1	Poly I-CIBA 08/2005
1	LeptinIBA 01/2005
1	CholesterolIBA 01/2005
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 12/2002

Therapy/Procedure

2	Therapeutics 12/2011 - 04/2011
1	Transplantation 03/2016